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KMID : 0387820120190020100
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Clinical Pediatric Hematology-Oncology
2012 Volume.19 No. 2 p.100 ~ p.104
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Two Cases of Autoimmune Neutropenia of Infancy
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Park Chung-Soo
Kang Ha-Ra
Ahn Young-Min
Won Dong-Il
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Abstract
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Autoimmune neutropenia of infancy (AIN) is caused by increased peripheral destruction of neutrophils as a result of antibodies in patients’ blood that are directed against their own neutrophils. Due to non-specific symptoms, benign clinical courses, and cumber-some diagnostic tests, AIN are commonly undetected. Antineutrophil antibody test for diagnosis of AIN has recently become available. Compared to its relatively lower abso-lute neutrophil count (ANC), the clinical course of AIN is mostly benign. Therefore, al-though treatment is not usually necessary for AIN, it is applicable in order to rule out other significant diseases, such as severe congenital neutropenia (SCN), which can be transformed to myelodysplastic syndrome or acute myelocytic leukemia. For this reason, several treatments can be used for neutropenia: granulocyte-colony stimulating factor (G-CSF) for SCN, trimethoprim and sulfamethoxazole (TMP-SMX) for prophylaxis. Here we report on two cases of AIN confirmed by indirect immunofluorescence test using flow cytometry.
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KEYWORD
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Autoimmune neutropenia, Antineutrophil antibody, Indirect immunofluorescence test
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